Symptoms include cardiac arrest and fainting due to a fast polymorphic ventricular tachycardia pattern, seizures, unexplained nighttime urination, and irregular breathing.

A diagnosis of Brugada syndrome is made with an abnormal resting ECG, ECG during fever, ECG with drug (procainamide) studies, and genetic testing. Genetic testing is positive in 40% of affected patients.

Treatment options are few. At present if a person has a definitive diagnosis and symptoms, an ICD is recommended. An ICD is not the answer for every patient. Some research suggests that quinidine may help some patients. Patients should also avoid drugs which block the sodium channels in the heart. Avoid drugs that can provoke the Brugada pattern.

Drugs to avoid for Brugada Syndrome patients

(information from SADS Foundation)

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